![]() ![]() Back to the example: if we bid 5 and get 7, then we get 2 bags.īags can also be bad. Sandbagging: Each trick we win that is over the bid is known as a bag. So if we bid 5, then get 4 tricks - we lose 50 points! Eek! This means we lose 10 points for each bid. However, if we don't get 5 tricks, we're in trouble. This means if my partner and I bid 5, then get 7 tricks, our total score for that round will come to 52. Additional tricks (overtricks) are only worth one point apiece. If you get exactly 5, you win 10x your bid, so 50 points. If you bid 5, you want to get at least 5. So we've already talked about how the goal is to get the number of tricks that you and your partner bid. The winner of each trick leads on the next.Īfter the first spade has been played, then spades are "broken." Scoring If no spades are played, the highest card wins of the suit that was played first. So even if someone plays the Ace of diamonds, and I play the 2 of spades, I win that trick if no other spades are played. If someone plays a spade, that spade trumps all other cards EXCEPT for higher spades. If you do not have the same suit, you can play any card of any suit! The card must be of the same suit as the person who started (in this case, the person to the left of the dealer). Then, again in clockwise, each player lays down a card (trick) face up. It can be any heart, diamond or club, but no spades. Playing SpadesĪfter all of the bidding is done, the player to the dealers left begins by playing any card EXCEPT for a spade. There's also a penalty for bidding nil and getting 1 or more tricks. Why would anyone do that though? Well, there's a huge bonus if you can bid nil and succeed. This is basically a player trying NOT to win any tricks. Billy and Sarah's goal is to win at least 5 tricks based on their bids (4+1), Terrance and Beyonce will attempt to win at least 7 (4+3).Īs mentioned previously, a bid of zero is also called a nil bid. A bid of zero or "nil" is another strategy we'll talk about shortly. But be smart and remember that it's very difficult to get all or even half of the tricks. Bidding then continues clockwise around the table. The first player to bid is the person to the left of the dealer. This is the number of tricks that team has to win in order to get a positive score. ![]() The teams then add together the total number of bids. ![]() Before each round of Spades begins, each player will bid (or guess) how many tricks they will take. Biddingīidding is simply guessing how many "tricks" you can take. The dealer will deal out all of the cards so each player will end up with 13 to start. The goal is to accumulate points, and the first to 500 points wins. You are on the same team as the person across from you and the same goes for the other two. There are too many options for spades games on the App Store to have to deal with these types of issues so I guess I will be on the lookout for a new spades app.In a typical game, there are four players and two team. I thought about upgrading to add free, but I read other reviews saying there are issues with that version too. Before the ads were introduced it was a great, 5 star app, but now it has dropped down to 1 star since I can’t even finish a game without it crashing. I just tried to play 3 different games and never got past 250 points because the game would crash and when I reopened the app, my progress was gone and I had to start a new game. It just seems they tried to push out the new version with ads before they had worked out all the bugs. When this happens, the app slows down to a crawl and eventually just crashes and loses the game progress. The ads do not appear on screen, but pop up in the background in the middle of a game and I can hear them while I am playing the game. I understand the need for the funding the ads generate and would be perfectly fine with it, but the ads do not work correctly. I have been using this app as well as many other Optime apps for years and they have always been great until the recent introduction of ads. ![]()
0 Comments
![]() In 1915, the unique father-and-son team of Sir William Henry Bragg and his son Sir William Lawrence Bragg were awarded a joint Nobel Prize for inventing the X-ray spectrometer and the then-new science of X-ray analysis. (The spacing of atoms in various crystals was reasonably well known at the time, based on good values for Avogadro’s number.) The experiments were convincing, and the 1914 Nobel Prize in Physics was given to von Laue for his suggestion leading to the proof that X-rays are EM waves. If a diffraction pattern is obtained, he reasoned, then the X-rays must be waves, and their wavelength could be determined. This was suspected from the time of the discovery of X-rays in 1895, but it was not until 1912 that the German Max von Laue (1879–1960) convinced two of his colleagues to scatter X-rays from crystals. Historically, the scattering of X-rays from crystals was used to prove that X-rays are energetic electromagnetic (EM) waves. Analysis of the pattern yields information about the structure of the protein. These can be studied using X-ray crystallography.įigure 4.24 X-ray diffraction from the crystal of a protein (hen egg lysozyme) produced this interference pattern. For example, more recent research in high-temperature superconductors involves complex materials whose lattice arrangements are crucial to obtaining a superconducting material. Not only do X-rays confirm the size and shape of atoms, they give information about the atomic arrangements in materials. This process is known as X-ray crystallography because of the information it can yield about crystal structure, and it was the type of data Rosalind Franklin supplied to Watson and Crick for DNA. (There is some debate and controversy over the issue that Rosalind Franklin was not included in the prize, although she died in 1958, before the prize was awarded.)įigure 4.24 shows a diffraction pattern produced by the scattering of X-rays from a crystal. For this work, Watson, Crick, and Wilkins were awarded the 1962 Nobel Prize in Physiology or Medicine. Using X-ray diffraction data produced by Rosalind Franklin, they were the first to model the double-helix structure of DNA that is so crucial to life. Perhaps the most famous example of X-ray diffraction is the discovery of the double-helical structure of DNA in 1953 by an international team of scientists working at England’s Cavendish Laboratory-American James Watson, Englishman Francis Crick, and New Zealand-born Maurice Wilkins. The process is called X-ray diffraction, and it involves the interference of X-rays to produce patterns that can be analyzed for information about the structures that scattered the X-rays. However, since atoms are on the order of 0.1 nm in size, X-rays can be used to detect the location, shape, and size of atoms and molecules. Thus, typical X-ray photons act like rays when they encounter macroscopic objects, like teeth, and produce sharp shadows. Since X-ray photons are very energetic, they have relatively short wavelengths, on the order of 10 −8 10 −8 m to 10 −12 10 −12 m. Describe interference and diffraction effects exhibited by X-rays in interaction with atomic-scale structures.By the end of this section, you will be able to: ![]() ![]() The aligned reads were obtained using the RNA-Seq Analysis Tool of CLC Genomics Workbench. The reference genome sequence and annotation files were downloaded from ENSEMBL, release.92 (Mus_musculus.GRCm38.92.fa, and Mus_musculus.GRCm38.92.gtf). Statistical analysis of differentially expressed genes is carried out based on a negative binomial model using a tool in CLC Genomic Workbench. The reference genome sequence and annotation files were downloaded from ENSEMBLE, release.92 (Mus_musculus.GRCm38.92.fa, and Mus_musculus.GRCm38.92.gtf). Bases with low quality were trimmed and reads are mapped to reference genome Mus musculus genome GRCm38. De-multiplexed fastq files from RNA-Seq libraries are imported into the CLC software. CLC Genomics Workbench 11.0.1 version ( Qiagen) was used for RNA-seq analysis. The sequencing of the cDNA libraries was performed on the Illumina NextSeq platform (Illumina, San Diego, CA) using the high output 1X75 cycles configuration. Methods: Illumina compatible RNAseq library was prepared using NEB next ultra RNAseq library preparation kit. The goals of this study are to compare NGS-derived brain transcriptome profiling (RNA-seq) to reveal the difference of cellular pathways in adult brains of wild type (WT) and monocyte-depleted (CCR2-DTR) mice 8 days post infection of Trichinella spiralis. Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. Next-Generation Sequencing Facilitates Quantitative Analysis of Wild Type and Monocyte-Depleted Brain TranscriptomesĮxpression profiling by high throughput sequencing ![]() GEO help: Mouse over screen elements for information. ![]() ![]() ![]() The horizontal scroll bar is located just above the status bar. The vertical scroll bar is located along the right side of the screen. The vertical and horizontal scroll bars enable you to move up, down, and across your window simply by dragging the icon located on the scroll bar. The Vertical and Horizontal and Vertical Scroll Bars The horizontal line next to the cursor marks the end of the document. As you type, your text displays at the cursor location. ![]() The blinking vertical line in the upper-left corner of the text area is the cursor. Just below the ruler is a large area called the text area. Click the check box next to Ruler in the Show/Hide group.If your ruler is not visible, follow the steps listed here: You can use the ruler to change the format of your document quickly. Clicking the dialog box launcher gives you access to additional commands via a dialog box. You may also find a dialog box launcher in the bottom-right corner of a group. You click buttons to issue commands or to access menus and dialog boxes. Within each group are related command buttons. At the top of the Ribbon are several tabs clicking a tab displays several related command groups. The Ribbon is located near the top of the screen, below the Quick Access toolbar. In Microsoft Word 2007, you use the Ribbon to issue commands. You use commands to tell Microsoft Word what to do. When you save your document, you assign the document a new name. As you open additional new documents, Word names them sequentially. Word names the first new document you open Document1. The Title bar displays the title of the document on which you are currently working. Next to the Quick Access toolbar is the Title bar. You can use Save to save your file, Undo to rollback an action you have taken, and Redo to reapply an action you have rolled back. By default Save, Undo, and Redo appear on the Quick Access toolbar. The Quick Access toolbar provides you with access to commands you frequently use. Next to the Microsoft Office button is the Quick Access toolbar. You can use the menu to create a new file, open an existing file, save a file, and perform many other tasks. When you click the button, a menu appears. In the upper-left corner of the Word 2007 window is the Microsoft Office button. ![]() ![]() So you could feature a mortgage lender on one panel of a three panel piece and charge him one-sixth of the total cost of the mailing. Per RESPA you cannot charge for space in your newsletter BUT you can get compensated for the exact amount of space they use on a print document. There have been studies that show seeing someone's face in a picture gives humans the same feeling of pleasure that actually seeing someone does. This is one place that you can have something like a “Lori's Corner” and get your face out there! ![]() It can be about current local market trends, national real estate news, home related items like preparing for winter, what hurricane season means to your insurance needs or even house care tips. ![]() This is a big one in addition to statistics for making your readers feel they got a value for their time. Few listings agents will say that you cannot help to market one of their properties. If you do not have your own types of these listings, ask someone in your office if you can “borrow” theirs. These should be listings be similar in price to the area you are mailing to OR a good move up price OR show that you are a luxury lister. You should have listing ads in your newsletter. A 10% absorption rate means that only 1 out of 10 homes are selling each month. You should also be sure to explain confusing terms like “absorption rate” in easy to understand english. If you are farming a neighborhood, it would be best to chunk it down to just that area. If you are doing a market area it is fine to use MLS wide statistics. ![]() Your Real Estate Agent Newsletter should contain… Market statistics It is actually amazing that we can send an email or two a month and let everyone know we care and are thinking about them or to mail a newsletter into an entire neighborhood and in one fell swoop let everyone know you are a neighborhood expert. Your Real Estate Newsletter should be a tool to talk with current, past and potential real estate clients. Here are my best Real Estate Newsletter Ideas, in no particular order. Because I help so many real estate agents with their marketing efforts, I KNOW that generating a monthly real estate newsletter can seem like an overwhelming task. ![]() ![]() ![]() The report said that after an “awkward silence” the instructor added, “that was a joke.” It said some candidates interpreted it as an implicit endorsement of using the drugs. And whatever you do, don’t get caught with them in your barracks room.” Don’t use PEDS, it’s cheating, and you don’t need them. In one case, it noted that during a discussion about the policy with Mullen’s class, an instructor, who was not identified, told sailors that all types of people make it through the course, including “steroid monkeys and skinny strong guys. The new report, however, suggests there may have been conflicting messages to candidates. In the wake of Mullen’s death, however, the command began some additional testing. The Navy has asked the department to do a study on testing and to allow random tests and sweeps for drugs, but those requests have not been approved by the Pentagon. Random testing for steroids wasn’t authorized by the Defense Department. The use of hair follicle testing was denied at least twice by Navy leaders over that time. Investigations in 2011, 20 into suspected steroid use by SEAL candidates led to discipline and requests for enhanced testing. The use of performance-enhancing drugs has been a persistent problem. ![]() The “ability to continue training through discomfort and some degraded physical condition was seen as a positive trait by instructors and this was understood by candidates,” the report said.Īs a result, candidates would push on and not tell medical staff or leaders about injuries, and there was pressure to use drugs to help keep them going. According to the Navy, about 888 SEAL candidates are considered every year, and the goal is to graduate 175. Compounding that problem, the report said, is that candidates were often reluctant to seek medical care because it would be seen as weak and could get them removed from the course or delay their completion. But it said SEAL instructors in recent years appeared to focus on weeding out candidates, rather than teaching or mentoring. The latest report notes that special operations forces are routinely required to carry out high-risk military operations, and thus require demanding training. ![]() ![]() ![]() The invention resides in passing the return conductor for the current traversing the fiuid in the duct back through the gap in the iron circuit of the pump. ![]() This patent reiates to electromagnetic pumps for electricity-conducting fluids and, in particular, describes several modifications for a linear conduction type electromagnetic interaction pump. Techniques for fabricating components of pump are discussed. Three phase helical, electromagnetic induction pump for use as boiler feed pump in potassium Rankine-cycle power system is described. ![]() PMID:23201986Īdvanced high-temperature electromagnetic pump Given an actuating voltage of 3 V and a driving frequency of 15 Hz, the flow rate is found to be 13.2 mL/min under zero head pressure conditions. The experimental results show that a coil input current of 0.4 A generates an electromagnetic force of 47 mN and a diaphragm deflection of 108 μm. The resulting bi-directional deflection of the PDMS diaphragm causes the check-valve to open and close thereby creating a pumping effect. When an AC current is passed through the microcoil, an alternating electromagnetic force is established between the coil and the magnet. The pump comprises four major components, namely a lower glass plate containing a copper microcoil, a middle PMMA plate incorporating a PDMS diaphragm with a surface-mounted magnet, upper PMMA channel plates, and a ball-type check valve located at the channel inlet. This study presents an electromagnetically-actuated reciprocating pump for high-flow-rate microfluidic applications. Ke, Ming-Tsun Zhong, Jian-Hao Lee, Chia-Yen Electromagnetically-Actuated Reciprocating Pump for High-Flow-Rate Microfluidic Applications ![]() ![]() He ruthlessly attacks the body, and knows how to play off his work to the legs and body to set up the kill shot to the head.Īs a wrestler, Benavidez has a deep understanding of how to implement his folkstyle background in mixed martial arts. ![]() On the feet, he is a combination counter puncher, he uses a power kicking game and some Duane Ludwig-inspired entries on the outside to trouble his opponents, punishing them with ugly, but brutal hooking combinations if they enter the pocket. Today, Joseph Benavidez has one of the most comprehensive skill-sets in the sport of mixed martial arts. Physical factors like chin and power factor in alongside more technical spheres. Quality Win #1: 2009 Joseph Benavidez (79)įighter rating are determined by how tough an out they are for any opponent, in a pound-for-pound sense. In fact, one fighter had an answer on the feet fairly early on. There is an existing narrative that no one could deal with Cruz’s “unorthodox” striking until he met TJ Dillashaw and Cody Garbrandt much later in his career. What set Cruz apart was how he capitalized on his mobility, picking up a few more advanced boxing techniques such as shifting, darts, pivots off entries, truly just the general theme of entering and exiting off angles was enough to trouble most fighters of his day in the WEC. The lower weight classes are proliferated by athletic wrestle-boxers, Cruz himself is no exception. Physicality is a factor, but Bowles was a fairly basic fighter, he never truly demonstrated the nuance or efficacy to prove himself as an elite. The curve is based on the best MMA fighter(s) we’ve ever seen to this point, so the goalposts to reach “100” status will move as the sport continues to age and evolve.ĭespite holding a major title, someone like Brian Bowles does not quite make the cut as far as “ratings” are concerned. The essential questions to answer are, “how good was (Fighter X) at the time Dominick Cruz defeated them? How tough were they to beat in that specific fight?” If we’re lacking data, “what form were they in at that stage of their career?” Method of victory, dominance, or other measures, would only add layers of subjectivity and muddy the process.Īt the most basic level we’re evaluating how hard that fighter is to beat, in a pound-for-pound sense. Instead, as the preamble suggests, I will be justifying the ratings of some of Dominick Cruz’s quality wins, in chronological order. ![]() If you were hoping for a more striking-centric breakdown, BJJ Scout has a few very popular videos on Cruz’s game. Wrestling for MMA: Dominick Cruz (UFC Career) Wrestling for MMA: Dominick Cruz (WEC Career) The skills of Cruz himself will hardly be touched, but if you’re interested, I have broken down his wrestling-focused game in two separate articles. Today, we’ll be looking at the resume of Dominick Cruz, the greatest bantamweight of all time. For a more in-depth explanation of that system, you can check out my section of our collective rankings page, or this document containing my own list, which includes the individual ratings of each quality win for dozens of candidates. I personally believe the closest we can get to objectivity is to attempt to rate quality wins, rather than symbolic accomplishments or contribution to the sport. ![]() There is no unified criteria among MMA fans or analysts in determining the all-time greats of the sport. ![]() Photo by Brandon Magnus/Zuffa LLC/Zuffa LLC via Getty Images ![]() ![]() Sign in with the Microsoft account that you used to buy your subscription, and then turn off recurring billing. You can cancel online by visiting the Microsoft Account site.Features and app availability may vary by region.What is a Microsoft account and why do I need it for Microsoft 365? You do not need to be connected to the Internet to use the Office apps, such as Word, Excel, and PowerPoint, because the apps are fully installed on your computer. To reactivate your apps, simply reconnect to the Internet. If you do not connect to the Internet at least every 31 days, your apps will go into reduced functionality mode, which means that you can view or print your documents but cannot edit the documents or create new ones. You should also connect to the Internet regularly to keep your version of Microsoft 365 up to date and to benefit from automatic upgrades. Internet access is also required to access documents stored on OneDrive, unless you install the OneDrive desktop app. Note that if you are an existing subscriber, you do not need to reinstall or purchase another subscription.įor Microsoft 365 plans, Internet access is also needed to manage your subscription account, for example to install Office apps on other PCs or to change billing options. Internet access is required to install and activate all the latest releases of apps and services included in all Microsoft 365 subscription plans. You can choose to pay for your subscription on a monthly or yearly basis, and the Microsoft 365 Family plan lets you share your subscription with your family for up to 6 people, and use your apps on multiple PCs, Macs, tablets, and phones. With a subscription, you'll always have the latest features, fixes, and security updates along with ongoing tech support at no extra cost. You also get extra online storage and cloud-connected features that let you collaborate on files in real time. Microsoft 365 includes the robust Office desktop apps that you’re familiar with, like Word, PowerPoint, and Excel. Microsoft 365 is a subscription that includes the most collaborative, up-to-date features in one seamless, integrated experience. However, there are no upgrade options, which means if you plan to upgrade to the next major release, you'll have to buy it at full price. One-time purchases are available for both PCs and Macs. ![]() Note: Please follow the steps in our documentation to enable e-mail notifications if you want to receive the related email notification for this thread.Office 2021 is sold as a one-time purchase, which means you pay a single, up-front cost to get Office apps for one computer. ![]() If you have extra questions about this answer, please click "Comment". If the answer is helpful, please click " Accept Answer" and kindly upvote it. After you enter the IID into the interface of the Phone Activation Wizard, you will get the Confirmation ID (CID) via phone, please continue to enter its value in Command Prompt to activate Office.Ĭscript.exe "%ProgramFiles%\Microsoft Office\Office16\ospp.vbs" /actcid:value.To get the Installation ID (IID) for offline activation for Office 2021, you may run following command in Command Prompt (Run as administrator).Ĭscript.exe "%ProgramFiles%\Microsoft Office\Office16\ospp.vbs" /dinstid.If you use MAK key to activate volume licensed Office 2021, yes, you need the Internet connection.īesides, please ensure your MAK key is correct.īut if you have no condition to connect to Internet, I suggest you choose "I want to activate the software by phone." ![]() ![]() To close the Anaconda Prompt, you can either close the window with the mouse, or type exit, no parenthesis necessary. The () is needed to stop the Python interpreter and get back out to the Anaconda Prompt. Note the double parenthesis at the end of the exit() command. To close the Python interpreter, type exit() at the prompt >. You should see the Zen of Python by Tim Peters With the interpreter running, you will see a set of greater-than symbols > before the cursor. You should see something like Python 3.6.1. The python command starts the Python interpreter, also called the Python REPL (for Read Evaluate Print Loop). The black screen and text that makes up the Anaconda Prompt doesn't look like much, but it is really helpful for problem solvers using Python.Īt the Anaconda prompt, type python and hit. ![]() Anaconda is the Python distribution and the Anaconda Prompt is a command line shell (a program where you type in commands instead of using a mouse). exe installerĪt the beginning of the install, you need to click Next to confirm the installation.Īt the Advanced Installation Options screen, I recommend that you do not check "Add Anaconda to my PATH environment variable"Īfter the installation of Anaconda is complete, you can go to the Windows start menu and select the Anaconda Prompt. Once the download completes, open and run the. The download is quite large (over 500 MB) so it may take a while to for Anaconda to download. You can still download Anaconda if you click and don't enter your Work Email address. If you are unsure if your computer is running a 64-bit or 32-bit version of Windows, select 64-bit as 64-bit Windows is most common. For problem solvers, select the Python 3.6 version. At the time of writing, the most recent release was the Python 3.6 Version. Select Windows where the three operating systems are listed.ĭownload the most recent Python 3 release. The Anaconda Downloads Page will look something like this: Open the Anaconda Prompt and run some Python code ![]() These three packages are very useful for problem solvers and will be discussed in subsequent chapters.įollow the steps below to install the Anaconda distribution of Python on Windows. Anaconda comes bundled with about 600 packages pre-installed including NumPy, Matplotlib and SymPy. Anaconda is free (although the download is large which can take time) and can be installed on school or work computers where you don't have administrator access or the ability to install new programs. I think the Anaconda distribution of Python is the best option for problem solvers who want to use Python. This section details the installation of the Anaconda distribution of Python on Windows 10. Installing Anaconda on Windows Installing Anaconda on Windowsįor problem solvers, I recommend installing and using the Anaconda distribution of Python. Problem Solving with Python Book Construction ![]() Open the Anaconda Prompt from the Windows start menu The Windows users can find an option in WinPython.5. Now, run the following command from the Linux terminal −Ĭanopy and ActiveState are the most sought after choices for Windows, macOS and common Linux platforms. You can choose between adding Anaconda in PATH variable and registering Anaconda as your default Python.įor installation on Linux, download installers for 32 bit and 64 bit installers from the downloads page − Installation is a fairly straightforward wizard based process. For installation on Windows, 32 and 64 bit binaries are available − The advantage of Anaconda is that you have access to over 720 packages that can easily be installed with Anaconda's Conda, a package, dependency, and environment manager.Īnaconda distribution is available for installation at. Package versions are managed by the package management system Conda. Matplotlib and lots of other useful (data) science tools form part of the distribution. The distribution makes package management and deployment simple and easy. Anaconda is a free and open source distribution of the Python and R programming languages for large-scale data processing, predictive analytics, and scientific computing. ![]() |